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Metformin is contraindicated in patients with renal disease or renal function, congestive heart failure requiring pharmacologic treatment, known hypersensitivity to metformin hydrochloride and acute or chronic metabolic acidosis including diabetic ketoacidosis, with or without coma.
Diabetic ketoacidosis should be treated with insulin.
Metformin should be temporarily discontinued in patients undergoing radiologic studies involving intravascular administration of iodinated contrast materials, because use of such products may result in acute alteration of renal function.
